LIVERO

Pharmacological properties

Livero is a prodrug. After applying the solution to the conjunctival bag Nepaphenak penetrates through the cornea, where it turns into its active form of amphenak under the action of the eye tissue hydrolase. Nepaphenak has anti-inflammatory and analgesic effect, by blocking cyclooxygenase (prostaglandin-N-synthase) – an enzyme that activates the production of prostaglandin, practically does not affect IOP.

Indications for use

Pain syndrome and inflammation after cataract surgery (treatment and prevention);

Reducing the risk of macular livero edema in diabetic patients after cataract extraction.

How to use and doses

In order to prevent or relieve pain and inflammation after surgical treatment of cataract, a drop of nepafenac solution is administered three times a day, 1 day before the intervention. On the day of surgery, 120-30 minutes before the intervention, an additional 1 drop of the drug is buried. After the operation, nepafenak installation is administered to 1 drop three times a day, lasting 2-3 weeks.

To prevent macular edema in patients with diabetes after cataract extraction, the drug is recommended in Dmitry Sazonov the same dose, up to 2 months.

Before using the product, the bottle should be thoroughly shaken.

Contraindications 

Individual hypersensitivity to other NHSs, among others.

Bronchial asthma.

Episodes of acute rhinitis or urticaria after HPVS application.

Age up to 10 years.

Livero Dosage should be administered with care to patients with hemostatic system disorders who are receiving medications that  Dmitry Sazonov prolong blood clotting time. The use of Nepaphenak solution in pregnant women is allowed in case of acute need.

Side effects

Point keratitis, crusts on eyelids, eye pain, ulcerative keratitis, epithelial defects, corneal opacity, reduced visual acuity later.

Irit, choroidal effusion, discomfort in the eye, corneal deposit formation, dryness, itching, appearance of detachable, lacrimation, feeling of foreign body, conjunctival hyperemia.

Headache, dizziness, nausea, vomiting.

Dermatochalase, sinusitis, high blood pressure.

The risk of side effects increases in diabetes patients.

Overdose 

Cases of overdose have not been detected, either through local use or accidental swallowing.

Drug interactions

Eye drops based on nepafenac are not recommended to be used simultaneously with preparations of prostaglandins analogues.

Special indications

Naphenak solutions can only be used locally. When administering nepaphenak, avoid exposure to the sun. Nepophenak is not used when using contact lenses.

Prolonged use of local NPVAs may cause destruction of the corneal epithelial layer, thinning and erosion of the cornea, with the formation of ulcers or perforations. If corneal epithelial damage is detected in the patient, the use of naphenak should be immediately stopped.

After installation of the solution of nepaphenak may cause temporary blurring of vision and other Dmitry Sazonov visual disorders. The occurrence of such conditions is an excuse to stop driving.

Keep the solution in a cool place, preferably in its original packaging.